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KMID : 0370220150590050215
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Yakhak Hoeji
2015 Volume.59 No. 5 p.215 ~ p.221
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Effect of Corticosterone Pretreatment on the Production of LPS-Induced Inflammatory Mediators in RAW 264.7 Cells
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채병숙:Chae Byeong-Suk
저자없음:No authors listed
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Abstract
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Glucocorticoids are known to have anti-inflammatory effect. To investigate whether corticosterone pretreatment enhances or not lipopolysaccharide (LPS)-induced production of inflammatory mediators, RAW 264.7 cells were pretreated with various concentrations of corticosterone for 24 h and then cultured without corticosterone in the presence or absence of LPS. Our results demonstrated that LPS remarkably increased production of TNF-α, IL-6, IL-1β, vascular endothelial growth factor (VEGF), and NO (nitric oxide). Corticosterone pretreatment significantly attenuated LPS-induced production of TNF-α, IL-1β, and VEGF, while significantly enhanced IL-6 and NO. These findings suggest that corticosterone pretreatment may contribute to LPS-induced inflammatory responses in macrophages via pro- and anti-inflammatory
imbalance of inflammatory mediators.
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KEYWORD
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corticosterone, TNF-α, IL-6, IL-1β, VEGF, NO, endotoxin
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